Growth rate of bones in rat foetal alcohol syndrome
نویسنده
چکیده
The effect of maternal alcohol consumption during pregnancy on the growth rate of humerus and femur were studied in 168 offspring of rats. Experimental foetal alcohol syndrome was produced by giving 10% ethanol (v/v) in water to eight-week-old female albino rats for 2 weeks, then 20% ethanol (v/v) for a further 3 weeks, and mating them overnight. When confirmed pregnant, the alcohol concentration was increased to 30% until delivery, when alcohol consumption was stopped. The control group was not given alcohol and both groups were fed ad libitum. Birth masses, as well as lengths of humerus and femur, of the control rats were significantly higher (P<0.01) than those of pre-natally alcohol-exposed rats at 3, 5, 7, 9, 11 and 14 weeks of age. There was no significant difference (P>0.05) between litter sizes of both groups. The relative growth rates of femur were significantly higher (P<0.01) in the experimental group than in the control group. These results suggest that the low birth masses observed in pre-natally alcohol-exposed rats did not depend on litter size. They also demonstrated that alcohol consumption by pregnant rats adversely affected the growth rates of humerus and femur of their offspring pre-natally, and this effect persisted throughout the period of this study.
منابع مشابه
Fetal Alcohol Syndrome
Background: About 40 thousand newborns are delivered annually with fetal alcohol syndrome (FAS). It induces serious CNS complications. Methods: In a review of, the word “fetal alcohol syndrome” was searched in PubMed and Google Scholar and the retrieved articles were summarized. Results: Many studies showed that alcohol can cause more defects in fetus than heroin, cocaine and marijuana. The pos...
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